error helper 1

[VCRvideocapturing]

There is no 'best denoiser' different denoisers work differently on different sources.
You still haven't answered whether the Avisynth Preview works or not. If the Preview does not work, neither will the encoding.
Since you are outputting YUV420 you can try, whether telling Hybrid to convert to the target color space at the beginning helps with your issues. ("Filtering->Avisynth->Misc->Source->Convert to target color space directly after the source filter" is the option to do this for Avisynth)
Maybe some one of the libraries used has a bug in its assembler routines, which are only triggered on systems,...

Cu Selur

I've never tried the Avisynth preview.
My file is originally YUV 4:2:2
Lagrith YUV 4:2:2 8bit
hybrid only has 4:2:0 8bit option for conversation.
(That's highlighted by default and in the menu x264 settings menu) it can't be changed I don't think?

Hybrid works as long as I don't choose any of the
Denoise filters.

Do the denoise filters work at your end?

My settings are: input source Lagrith 4:2:2 file
Hybrid media info side panel
Scan type progressive(wrongly flagged)
4:2:2 tv 8bit
Size 720x576
Resize tab set to to 1920x1080 or 4k for YouTube clips.

Avisynth selected for de-interlacing.
QTGMC}ignore input scan type
changed to TFF(upper field first)

If using just these settings things work fine, if I add filters}DeNoise}Mclean then helper 1 error.

Can you check to see if you can successfully encode with any of the denoise plug ins selected?

I'm sure I've used a de-noise filter in a previous version and it worked just fine with the above settings. I just can't remember what one it was and what has changed in this version?